Comparative study different brands of azithromycin tablets
Pervin, Most. Shahnaj
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ABSTRACT Azithromycin belongs to the family of medications known as macrolide antibiotics. It is used to treat certain types of infections that are caused by bacteria. It is most commonly used to treat ear infections (e.g., otitis media), throat infections, lung infections (e.g., pneumonia), and skin infections. It can also be used to prevent mycobacterium avium complex (MAC) infections in people with HIV infection.The purpose of this study was to determine the pharmaceutical quality of the Azithromycin tablets dispensed in Bangladesh. The organoleptic and physicochemical properties of five different brands of Azithromycin tablets were assessed according to established methods. The results of weight variation, disintegration time, dissolution time, drug content and drug release of all marketed products comply with established limit. The qualitative and quantitative parameters of all the tested samples complied with the USP reference standard which is a reflection of quality product of azithromycin in Bangladesh local market. Result: The result showed that, five brands of Azithromycin tablets , meet a good result for weight variation, friability, disintegration time and dissolution rate. But one brand of tablets showed slow dissolution rate as compared to USP specificationailed to meet the USP specification. Conclusion: The present study, Although performed on a limited scale yet on the basis of professional judgment the data reported in this study can help the Drug Control Authority to get an idea about the quality status of the marketed Azithromycin preparations in Bangladesh.